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Carbon monoxide (CO) poisoning. A faulty natural gas room heater caused this fatal poisoning. The characteristic cherry-red coloration of skin persists in death. CO binds irreversibly with hemoglobin to produce bright red hemoglobin‚ which retains its color even though no oxygen is present.
- Carbon monoxide (CO) is a leading cause of poisoning death in the US . CO is an odorless, tasteless, colorless gas produced by combustion of carbon-containing compounds (wood, charcoal, oil, gas):
- CO inhalation leads to displacement of oxygen from binding sites on hemoglobin.
- Detrimental effects are related to tissue hypoxia from decreased oxygen content and a shift of the oxyhemoglobin dissociation curve to the left.
- CO also binds to mitochondrial cytochrome oxidase, impairing adenosine triphosphate (ATP) production, and to myoglobin, affecting muscle function.
- System(s) affected: Cardiovascular; Musculoskeletal; Nervous